Tissue Injury & Regenerative Medicine
The charge of the Tissue Injury and Regenerative Medicine (TIRM) Project Management Office (PMO) is to deliver solutions that restore form, function and appearance to wounded Warfighters. We take the dreams of scientists and shape them into clinical realities.
The TIRM PMO addresses challenges to medical product innovation through two lines of effort: (1) Product Development and (2) Biomanufacturing Innovation.
Our team of experts includes the Department of Defense acquisition and project management professionals, clinicians, engineers, scientists, and entrepreneurs who work together to identify promising products to fit military needs through market research and due diligence. The team provides coaching and mentorship to new companies or investigators in order to mitigate risks during development, to optimize regulatory and business strategies, and get the product to the clinic, and our Warfighters, as quickly as possible.
Our technology sectors include extremity and craniomaxillofacial regeneration, vascularized composite allotransplantation, advanced prosthetics, sensory restoration or regeneration, and the enabling technologies needed to support these advancements.
- Extremity Injury Repair: This focus area aims to develop a 'toolkit' of regenerative medicine products for the trauma and reconstructive surgeon to restore function to wounded extremities. Novel products will also improve limb salvage rates, decreasing the need for amputation following severe trauma, and restoring appearance. Extremity reconstruction requires products that can heal and regenerate damaged blood vessels, nerves, muscles and bones. Ideal products will heal multiple tissues simultaneously to repair complex injuries, recognizing the interdependent developmental pathways required to restore full form and function. They will exceed outcomes with current standards of care using autologous tissues and/or synthetic materials.
- Craniomaxillofacial (CMF) Injury Repair: This focus area aims to deliver products that improve and restore function and appearance after severe facial injury. Facial reconstruction relies heavily on autologous tissues to rebuild lost structure and function. Unfortunately, tissues from other body regions are poor substitutes for the unique tissue of the face. The CMF focus area targets new ways to reduce scarring and fibrosis, prevent infection, and regenerate muscle, nerve and facial tissues to restore the exquisite architecture of the face with high fidelity.
- Burn Injury Treatment and Skin Repair: This focus area aims to deliver products that provide those who have sustained severe burn injuries with the opportunity to recover faster from their injuries with improved function and appearance. Areas of interest include developmental products to prevent burn progression, regenerate functional skin, and to treat burn wound scarring.
- Vascular Composite Allotransplantation: This focus area aims to deliver products to advance the field of transplantation of composite tissues such as hand, arm and face transplants and research into the management of life-long immune suppression required to preserve the function of transplanted tissues.
- Complex Wound Repair: This focus area aims to optimize healing of complex wounds by minimizing the risk of infection and establishing a favorable environment for wound repair.
- Pharmaceutical Interventions for Noise-Induced Hearing Loss: This focus area aims to develop the first FDA-approved pharmacological preventive and/or restorative interventions for noise-induced hearing loss for Service Members to compliment current hearing protection strategies. Service Members are vulnerable to noise-induced hear loss resulting from exposure to inherently noise-hazardous environments. Despite existing hearing protection strategies, hearing loss continues to be the second highest service-related disability claimed over the last decade.