Pharmaceutical Systems centrally manages the development and acquisition of pharmaceutical and biological products (drugs, vaccines, diagnostics, protective and therapeutic modalities for use against infectious diseases and similar products for combat casualty care). Product Managers work with USAMRMC laboratories, academia, and industry partners (both domestic and foreign) to identify, develop, license, and field products to remedy deficiencies identified by the Army Medical Department Combat Developer.
Below are examples of a few products in the current development portfolio of Pharmaceutical Systems:
Adenovirus Vaccine, Types 4 & 7
Adenovirus vaccine is used by the
Department of Defense to prevent adenovirus type 4- and 7- related
acute respiratory disease in military recruits during basic
training. Because adenoviruses can spread via direct contact and
airborne and droplet transmission, the close quarters and
barracks-style living, combined with the stress of basic training,
make recruits highly susceptible to exposure and infection.
Adenovirus infections in military recruits have been associated with pharyngitis, conjunctivitis, rhinitis and pneumonia. These illnesses have led to missed training and recycling of recruits through the training cycle, in addition to outpatient visits and hospitalizations. In the period before the adenovirus vaccine capability was restored in late 2011, adenoviruses caused about 15,000 cases of acute respiratory disease in recruits each year.
Adenovirus Vaccine is supplied as two orally administered, enteric coated tablets containing live adenovirus serotypes 4 and 7. Each initial-entry recruit receives a one-time dose of both serotypes, along with other immunizations, during in-processing.
The Adenovirus Vaccine was U.S. FDA approved in March 2011. The U.S. military began administering the vaccine to recruits in basic training in late October 2011. Since then, the number of adenovirus-related respiratory infections among recruits has declined by about 99%.
Adenovirus Vaccine Fact Sheet (652 KB)
Topical Paromomycin will be an easy-to-use topical cream containing the antibiotics paromomycin and gentamicin. This product is under development as a self-administered treatment for simple and uncomplicated Old World Cutaneous Leishmaniasis (LEASH-ma-NIGH-a-sis).
Although CL is usually a non-life threatening disease, it can be mutilating and disfiguring. Topical Paromomycin is being developed by the U. S. Army Medical Research and Materiel Command (USAMRMC) as a first-line chemotherapeutic drug that may be easily used and self-administered.
It provides an effective treatment option to caregivers to sustain Soldiers and unit performance by:
Topical Paromomycin Fact Sheet (562 KB)
Intravenous Artesunate (IV AS)
Artemisinin, the naturally-isolated parent drug of artesunate, is extracted from 'qing hao' or sweet wormwood (Artemisia annua L.). It has been part of traditional Chinese herbal medicine for centuries. Artesunate was rediscovered and isolated as the active antimalarial agent in Artemisia annua L. in 1972 by Chinese scientists, and later independently by scientists at the Walter Reed Army Institute of Research seeking new treatments for malaria.
The Investigational New Drug Application (IND) for an intravenous (IV) formulation of the drug to treat severe and complicated malaria was filed November 30, 2004. The U.S. Army is currently seeking approval for IV Artesunate from the U.S Food and Drug Administration within the next five years. In the treatment of severe malaria, IV AS has a rapid onset of action, is safer and simpler to administer than current treatments and has shown to be highly effective. To date, over 300 people with severe and complicated malaria have been treated with IV AS under two treatment protocols. IV AS will be available to U.S. citizens, including U.S. Service Members, following U.S. FDA approval.